Bumped kinase inhibitor 1294 treats established Toxoplasma gondii infection.
نویسندگان
چکیده
Toxoplasma gondii is a unicellular parasite that causes severe brain and eye disease. Current drugs for T. gondii are limited by toxicity. Bumped kinase inhibitors (BKIs) selectively inhibit calcium-dependent protein kinases of the apicomplexan pathogens T. gondii, cryptosporidia, and plasmodia. A lead anti-Toxoplasma BKI, 1294, has been developed to be metabolically stable and orally bioavailable. Herein, we demonstrate the oral efficacy of 1294 against toxoplasmosis in vivo.
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 58 6 شماره
صفحات -
تاریخ انتشار 2014